Amsterdam combines the unrivaled beauty of the 17th-century Golden Age city center with plenty of museums and art of the highest order, not to mention a remarkably laid-back atmosphere. It all comes together to make this one of the world's most appealing and offbeat metropolises in the world. Built on a latticework of concentric canals like an aquatic rainbow, Amsterdam is known as the City of Canals—but it's no Venice, content to live on moonlight serenades and former glory. Quite the contrary: on nearly every street here you'll find old and new side by side—quiet corners where time seems to be holding its breath next to streets like neon-lit Kalverstraat, and Red Light ladies strutting by the city's oldest church. Indeed, Amsterdam has as many lovely facets as a 40-carat diamond polished by one of the city's gem cutters. It's certainly a metropolis, but a rather small and very accessible one. Locals tend to refer to it as a big village, albeit one that happens to pack the cultural wallop of a major world destination. There are scores of concerts every day, numerous museums, summertime festivals, and, of course, a legendary year-round party scene. It's pretty much impossible to resist Amsterdam's charms. With 7,000 registered monuments, most of which began as the residences and warehouses of humble merchants, set on 160 man-made canals, and traversed by 1,500 or so bridges, Amsterdam has the largest historical inner city in Europe. Its famous circle of waterways, the grachtengordel, was a 17th-century urban expansion plan for the rich and is a lasting testament to the city’s Golden Age. This town is endearing because of its kinder, gentler nature—but a reputation for championing sex, drugs, and rock ’n’ roll does not alone account for Amsterdam's being one of the most popular destinations in Europe: consider that within a single square mile the city harbors some of the greatest achievements in Western art, from Rembrandt to Van Gogh. Not to mention that this is one of Europe's great walking cities, with so many of its treasures in the untouted details: tiny alleyways barely visible on the map, hidden garden courtyards, shop windows, floating houseboats, hidden hofjes(courtyards with almshouses), sudden vistas of church spires, and gabled roofs that look like so many unframed paintings. And don’t forget that the joy lies in details: elaborate gables and witty gable stones denoting the trade of a previous owner. Keep in mind that those XXX symbols you see all over town are not a mark of the city's triple-X reputation. They're part of Amsterdam's official coat of arms—three St. Andrew's crosses, believed to represent the three dangers that have traditionally plagued the city: flood, fire, and pestilence. The coat's motto ("Valiant, determined, compassionate") was introduced in 1947 by Queen Wilhelmina in remembrance of the 1941 February Strike in Amsterdam—the first time in Europe that non-Jewish people protested against the persecution of Jews by the Nazi regime.

DÜSSELDORF. As a leading hub for German culture, commerce and architecture, Düsseldorf is a must-visit city for any travelers on the Rhine. Here, you will have multiple options for the day’s excursion. Explore this grand city on the Rhine by joining a walking tour, concluding with a tasting of Altbier, a local specialty brewed using traditional techniques. If you’re feeling adventurous, take a brief trip to the nearby city of Cologne. Join a guided tour through the enchanting Old Town, where you will see sites such as the Cologne Rathaus, Germany’s oldest town hall; the Fishmarkt, which dates back to the 12th century and the Great St. Martin Church. (B,L,D)

Rudesheim am Rhine is a town in the Rhine Valley in Germany and part of the UNESCO World Heritage Site of Rhine Gorge. It is known for its production of Riesling wine and has been popular for its wine making since ancient times. The Medieval Bromserburg Castle is home to the Rheingau Wine Museum and wine is a crucial part of Rudesheimer culture. The town is surrounded with vineyards and wineries, as well as many local wine bars and seasonal wine taverns. Wine tasting is a must do in Rudesheim and dining out is a great accompaniment. The local cuisine is seasonal and is closely intertwined with the wine growing traditions together with soups such as Zwiebelkuchen, Handkäs mit Musik and Spundekäs. Nordic Walking is popular around town, with five adventure trails around the vicinity, as well as many popular cycling routes. Great views of the town can be found from the water, the cable car to Niederwald Monument and the Monument itself. Old Town has the best examples of the town’s architecture with Eagle Tower, Oberstrasse and Rheinstein Castle some key sites to visit.

LUDWIGSHAFEN. Ludwigshafen is your gateway to a choice of three excursions. Visit Heidelberg, the perfectly preserved medieval city nestled in the Neckar River Valley along Germany’s Castle Road. Discover the iconic red sandstone Heidelberg Castle and Great Vat, an 18th-century, 49,000-gallon wine cask. For a more active adventure while in Heidelberg, join a guided hike up the Philosopher’s Path, aptly named during the Romantic Period, and enjoy panoramic views of the city. Alternatively, you can visit one of Germany’s oldest cities, Speyer, known for the largest Romanesque cathedral in Europe—a UNESCO World Heritage Site—and the medieval Old Gate, Altpörtel. Or join a guided bike tour along the shores of the river Neckar and enjoy a cycling break to explore the picturesque medieval town of Ladenburg. (B,L,D)

STRASBOURG, FRANCE. Strasbourg offers flavors of both France and Germany because of its borderline location. Enjoy walking through the iconic “La Petite France” district, lifted straight from the pages of a fairytale. Wander through charming streets past the Cathédrale de Nôtre Dame with its famous astronomical clock. Alternatively, take a guided bike ride through the city and Parc de l’Orangerie. (B,L,D)

Breisach is a town located in Southwest Germany on the French border. The town is situated in the Rhine Valley on the banks of the river Rhine and dates back over four thousand years. Breisach and its history can be experienced through the City History Museum, which houses a permanent exhibition taking you from Stone Age through the Celtic, to the Romans and Middle Ages, right up to modern day. St Stephen's Cathedral is home to the city’s famous art treasures, the wheel wells, which are housed in the neighbouring Radbrunnenturm with the forty one metre deep water well. The cathedral is also home to many other treasures including the High Altar of Master HL and wall paintings by Martin Schongauer as well as High Gothic and Roman architecture. A visit to the Blue House, the former Jewish Community Centre, is highly recommended. Now owned by the Friends of Former Jewish Community House Breisach it exhibits memorials to Breisach’s Jewish heritage.

Basel is a city in northwestern Switzerland on the Swiss, French and German borders. It is located on the bend of the River Rhine and benefits from a Mediterranean climate. It is the third most populated city in Switzerland and has been the commercial hub for Swiss arts and culture since the Renaissance. In 1967 the people of Basel voted to acquire two paintings by Picasso, who was so moved by the Basel people that he donated 3 paintings and a study to the city's Kunstmuseum (Museum of Fine Arts). Visit the Augusta Raurica, one of the largest Roman archaeology parks in Switzerland, and enjoy a river crossings over the River Rhine by non-motorised ferries. During the summer months, time is spent outdoors, either swimming in the River Rhine, dining al fresco, enjoying open air concerts, cinema, street parties and festivals. Basel is home to over 20 restaurants that have won GaultMillau or Michelin awards, and boasts Switzerland's largest collection of theatre shows, including modern contemporary dance, touring and puppetry theatre.