RÉGUA. Arrive in Régua, the gateway to Portugal’s World Heritage-listed Alto Douro Wine Region, and enjoy a traditional Portuguese lunch at a nearby quinta. Then, choose between an educational afternoon voyage to either the 18th-century baroque Casa Mateus with its remarkable gardens or the Amadeo de Souza-Cardoso Museum which showcases works by Portugal’s modernist and contemporary artists.

VEGA DE TERRÓN, SPAIN. Spend the morning taking in the scenic beauty of the port before choosing an educational voyage in the afternoon. Choose between exploring the Côa Valley Archaeological Park with its millennia-old Paleolithic rock art, meandering through the historic hilltop village of Castelo Rodrigo, or hiking to the village while enjoying panoramic views of the Douro Valley. Spend the night docked just across the border on the Spanish side of the river.

VEGA DE TERRÓN, SPAIN – SALAMANCA. Take a day trip to Salamanca and explore its UNESCO-listed old town, where Gothic, Moorish, Renaissance, and Baroque architecture tells the story of the city’s history. On the tour, see sites like the Plaza Mayor, historic university buildings, and the New Cathedral. Later, visit the Palacio de Monterrey to study its Spanish Renaissance design and celebrated artworks.

PINHÃO. Spend time soaking up the beauty of the Douro River as you cruise to Pinhão. Be treated to an exclusive lunch at Quinta da Avessada, where you’ll enjoy an authentic and traditional dining experience complete with entertainment. Quinta da Avessada is also a fascinating interactive museum commemorating the history and culture of wine in the Alto Douro region, so you’ll have fun discovering all the various stages of wine production as well as doing plenty of tasting. Savor the flavors of Portugal’s renowned fortified wine, vinho do porto, made exclusively in the Douro Valley. Head to a local quinta for your authentic Port-wine tasting experience and enjoy the sweet nectar of this fascinating region. (B,L,D)

RÉGUA. Travel to Lamego to explore the 18th-century pilgrimage shrine of Nossa Senhora dos Remédios, famous for its stunning blue-and-white azulejos. For a more active experience, climb the nearly 700-step zigzagging staircase up to the shrine. Afterward, descend into the heart of the town to sample local specialties, including bôlas de Lamego, presunto, and Portuguese sparkling wine.

Lively, commercial Oporto is the second largest city in Portugal after Lisbon. Also called Porto for short, the word easily brings to mind the city's most famous product - port wine. Oporto's strategic location on the north bank of the Douro River has accounted for the town's importance since ancient times. The Romans built a fort here where their trading route crossed the Douro, and the Moors brought their own culture to the area. Oporto profited from provisioning crusaders en route to the Holy Land and enjoyed the riches from Portuguese maritime discoveries during the 15th and 16th centuries. Later, port wine trade with Britain compensated for the loss of the spice trade and the end of gold and gem shipments from Brazil. In the 19th century, the city went through a period of new prosperity with the rise of industries. In its wake followed the building of workers' quarters and opulent residences. Since the declaration of Oporto as a World Heritage Site by UNESCO, the city aims to build up a cultural reference that will provide it with a new image, based on deep historical roots. Among the attractions that make Oporto such an interesting place are its graceful bridges spanning the Douro River, a picturesque riverfront quarter and, most notable, its world-famous port wine lodges. Although Oporto is a bustling centre and home to many different businesses, the source of its greatest fame is the rich, sweet fortified red wine we know as port.

Lively, commercial Oporto is the second largest city in Portugal after Lisbon. Also called Porto for short, the word easily brings to mind the city's most famous product - port wine. Oporto's strategic location on the north bank of the Douro River has accounted for the town's importance since ancient times. The Romans built a fort here where their trading route crossed the Douro, and the Moors brought their own culture to the area. Oporto profited from provisioning crusaders en route to the Holy Land and enjoyed the riches from Portuguese maritime discoveries during the 15th and 16th centuries. Later, port wine trade with Britain compensated for the loss of the spice trade and the end of gold and gem shipments from Brazil. In the 19th century, the city went through a period of new prosperity with the rise of industries. In its wake followed the building of workers' quarters and opulent residences. Since the declaration of Oporto as a World Heritage Site by UNESCO, the city aims to build up a cultural reference that will provide it with a new image, based on deep historical roots. Among the attractions that make Oporto such an interesting place are its graceful bridges spanning the Douro River, a picturesque riverfront quarter and, most notable, its world-famous port wine lodges. Although Oporto is a bustling centre and home to many different businesses, the source of its greatest fame is the rich, sweet fortified red wine we know as port.